Looking to open or relocated your business to Madison County, IL? Here you will find our complete listing of available Commercial Properties in Madison County, Illinois including, but not limited to Commercial Development Sites, Industrial Properties and Investment Properties for Sale as well as Retail and Office Space for Lease.
BARBERMURPHY has several Madison County IL Commercial Properties for Sale or Lease to choose from.
Visit the Properties Page on our Website to see all available Madison County IL Commercial Properties for Sale or Lease https://barbermurphy.com/properties/
Madison County IL Cities
Alton
Adventure Bay (little bit in St. Clair County)
Collinsville (partly in St. Clair County)
Edwardsville
Fairmont City
Godfrey
Granite City
Highland
Madison
Roseville
Troy
Venice
Madison County IL Villages
Alhambra
Ainklen
Ameren
Bethalto
East Alton
Glen Carbon
Grantfork
Hamel
Hartford
Livingston
Marine
Meepland
Maryville
New Douglas
Pontoon Beach
Pierron
Roxana
South Roxana
Madison County IL Property Lookup
Current Madison County IL Commercial Properties for Sale or Lease
5.22 Acre Office/Retail Development Site
5.22 Acres of land located and fronting Vaughn Road/111. Office/Retail development. All utilities on/adjoining site.Located 1/4 mile from Interstate 255 exit and abuts 255 to the rear of the property. Office, retail and residential surrounding the property. St. Louis Regional Airport 1/4 miles to the East.
(2) Commercial Development Sites
Two Commercial Lots for Sale. All utilities on site.Lot 1 - 1.35 Acre Commercial Development Site Located off of East Hwy 40 with an approved entrance next to Casey's. 91' of frontage.Sale Price: $176,418Lot 2 - 2.34 Acre Commercial Development SiteLocated on East Hwy 40 in Troy zoned C-3 Hwy Commercial. 263' of frontage.
20+ Acre Commercial Site
20+ AC in the heart of Edwardsville, IL. Zoned Commercial. Located less than 5 minutes from Southern IL University (SIUE) campus or downtown Edwardsville and the Madison County courthouse. Site of the former Gateway Regional Medical Center (33,000+ SF).Located on University Dr. near the intersection of IL-157 and University Dr.
For Sale 3,021 SF Medical Office Condo
3,021 SF Medical Office Condo for Sale or Lease. Located in Bellmore Medical Building. The condo was renovated in 2024. This is in a heavy business district. The space contains 2 reception areas, 4 restrooms, lab, and 10 offices. 2024 HOA is $2400 annually. Other users in the building are SSM Healthcare and Bradford Eye Care.Located 1 block off Nameoki Rd.
Religious Facility & Parsonage
4,640 SF Church Building and a 1,242 SF House For Sale.Church has a 40x40 SF Sanctuary with pews, baptismal and sound system, two large open meeting areas, a small kitchen and two offices.Parsonage is 1,242 SF and has 3 bedrooms and 1 bathroom and will need to be completely remodeled.Located on Maryville Rd., 4.0 miles east of I-255.
3,600 SF Warehouse - New Construction
3,600 SF warehouse space available for lease. O'neil Construction completed the building at the end of 2024 and finishing touches were completed in February 2025. 14' x 12' drive-in door opens to a 3,000 sf space with 16' ceilings, 5" thick concrete floor, ADA restroom, small storage room with water heater and slop sink, and a small office up front. Office, restroom and storage have HVAC control.
Up to 48,000 SF Service Center/Warehouse Spaces - March 2026 Delivery
NOW LEASING BLDG 1 - MARCH 2026 DELIVERY(2) 48,000 SF Warehouse/Service Buildings. Each building consists of (5) 9,600 SF bays (divisible to approx. 4,600 SF), (10) 9'x10' dock doors per building with (1) 6'x6' dock leveler with shroud and bumpers. Additional 12'x14' OH door knockout available. 10% office buildout per bay.Located near the intersection of Horseshoe Lake Rd. and McDonough Lake Rd.
0.20 Acre Commercial Site
Last remining lot in the well-established Sunset Hills Professional Centre office park. Located directly across from Sunset Hills Country Club on IL-157. Easy access from the Hwy. 5 minutes from I-270 and 10 minutes from downtown Edwardsville. Subject to the recorded covenants and restrictions for the office park. Broker Owned.Lot 7 in the Sunset Hills Professional Centre office park.
1,200 SF for Lease
Private office space available in this newly remodeled Bank of Hillsboro branch. Easily accessible from IL-157, IL-140 and I-55. Tenant improvements negotiable.Located at the corner of IL-157 and State St (IL-140).Lease Rate: $10.
7,200 SF Office/Warehouse
Office/WarehouseThis 7,200 SF office/warehouse is situated on .9 acres. It has 1,440 SF of office space and 5,760 SF of warehouse space. (1) 8'x8' grade level door. Ceiling heights are 10' tall. Asphalt parking lot.This property is located in Granite City, IL 15 minutes from downtown St. Louis just off of Route 3 with easy access to I-70 and I-270.
1,619 SF Office Building
Office BuildingWell-located 1,619 SF office building with kitchenette, conference room, private offices, upstairs work space. Dedicated parking in the downtown corridor. Adjacent to restaurants, shops, and other businesses.Very attractive downtown location in growth market of Edwardsville IL. Located on S. Main street one block off of Main and Vandalia.
Medical Office Space for Lease
Medical OfficeHighly visible medical office building in Edwardsville. Easy access from IL-159 with 24,000+ ADT. Less than 1 mile from I-270 (Exit 12).Main Floor is a former urgent care facility that includes 7 exam rooms, x-ray and small procedure room (see floor plan.