Looking to open or relocated your business to Madison County, IL? Here you will find our complete listing of available Commercial Properties in Madison County, Illinois including, but not limited to Commercial Development Sites, Industrial Properties and Investment Properties for Sale as well as Retail and Office Space for Lease.
BARBERMURPHY has several Madison County IL Commercial Properties for Sale or Lease to choose from.
Visit the Properties Page on our Website to see all available Madison County IL Commercial Properties for Sale or Lease https://barbermurphy.com/properties/
Madison County IL Cities
Alton
Adventure Bay (little bit in St. Clair County)
Collinsville (partly in St. Clair County)
Edwardsville
Fairmont City
Godfrey
Granite City
Highland
Madison
Roseville
Troy
Venice
Madison County IL Villages
Alhambra
Ainklen
Ameren
Bethalto
East Alton
Glen Carbon
Grantfork
Hamel
Hartford
Livingston
Marine
Meepland
Maryville
New Douglas
Pontoon Beach
Pierron
Roxana
South Roxana
Madison County IL Property Lookup
Current Madison County IL Commercial Properties for Sale or Lease
4,195 SF Office/Retail Space
4,195 SF retail/office/potential medical buildout. Space is divisible and will be delivered in white-box condition, with an outdoor patio and a large parking lot. Excellent retail opportunity with a large patio. Currently has 2 finished ADA bathrooms.Located just down the street from Anderson Hospital. The main road provides access to Highway 159 and Hwy 162.
5.8 Acre Commercial Lot
The Wood River community is part of the River Bend region, which has nearly 200,000 residents. That region, encompassing 13 individual communities, generates more than $1.7 billion in total sales annually.
Multi-Family Investment Opportunity
13 Unit all-brick apartment complex consisting of 2 buildings. There are (8) 1 Bedroom units and 4 studio apartments. The basement is available as an apartment. Fully leased out to Chestnut Health Systems, with the exception of the basement. Landlord pays property taxes, insurance, and utilities.Located approximately 10 miles northeast of St. Louis, MO and is part of the Metro-East region.
9,724 SF Office/Retail Building
Mixed office/retail space. Combined two and one-story building space with a basement. On street and city parking lot adjacent to the building. Employee parking is located in the rear of the building.Excellent mixed-use office/retail space located on Collinsville's main street. The building features a highly visible storefront and could facilitate multiple businesses in a single location.
3,290 SF Office Building
3,290 SF standalone office building for sale and lease in the well-established Sunset Hills Professional Centre located off IL-157 in Edwardsville’s office/medical corridor. The main level consists of 7 private offices, 2 restrooms, an IT room, a conference room, and an open bullpen in the middle with a small reception area inside the entrance.
3,982 SF Class A Professional Office Space
3,982 SF Class A office suite available for lease. Suite features 3 private offices, conference room, large training/conference room, open concept kitchenette and bullpen, along with an IT Rack and storage.
Shovel Ready Development With Incentives
(2) 48,000 SF Warehouse/Service Buildings. Each building consists of (5) 9,600 SF bays (divisible to approx. 4,600 SF), (10) 9'x10' dock doors per building with (1) 6'x6' dock leveler with shroud and bumpers. Additional 12'x14' OH door knockout available. 10% office buildout per bay.Located near the intersection of Horseshoe Lake Rd. and McDonough Lake Rd., less than 1/2 mile off I-255 (exit 26).
Investment Opportunity: Multi-Tenant Property
Multi-Tenant investment property featuring a diverse range of spaces, including a restaurant, distillery, brewery, lounge, event space, sports bar, and a barber shop. Additionally, it includes a beer garden equipped with a concession stand, restrooms, and an elevated stage.One block south of Illinois 159 in Downtown Collinsville.
1,750 SF Office Suite
1,750 SF Available for LeaseLocated at 24A Professional Park in Maryville, this 1,750 SF office suite is move-in ready and well suited for medical, professional service, financial, or general office users. The suite includes five private offices, a reception area, two bathrooms, and a kitchenette. Renovated in 2026, the space features updated flooring and lighting throughout.
5,145 SF Buildout Ready Lower Level Suite
5,145 SF unfinished lower level suite available for lease. Suite is climate-controlled with individually-metered utilities. Walk-out entrance to the South and 3 points of entry to the suite. Lower level common hallways and restrooms (4) are shared with co-anchor tenants Bank of Springfield and SSM Health.
11,946 SF Healthcare Office Building
11,946 SF office (3,982 SF per floor) available for sale. This former healthcare office profiles well for an owner/user with multiple tenants (6 meters) or one, large end-user. The facility is ADA accessible on the main level via a ramp as well as the lower level with walk out accessibility. The entrance to each floor has a vestibule with an elevator and staircase.
840 SF - 2,088 SF Professional Office Suites
Well-maintained brick office building featuring a professional exterior, attractive landscaping, and flexible floor plans designed to accommodate a variety of office users. The property offers a welcoming professional atmosphere with quality interior finishes, ample parking, and efficient layouts suitable for general office, medical, counseling, financial, and service-oriented businesses.