20+ AC in the heart of Edwardsville, IL. Zoned Commercial. Located less than 5 minutes from Southern IL University (SIUE) campus or downtown Edwardsville and the Madison County courthouse. Site of the former Gateway Regional Medical Center (33,000+ SF).Located on University Dr. near the intersection of IL-157 and University Dr.

3,600 SF warehouse space available for lease. O'neil Construction completed the building at the end of 2024 and finishing touches were completed in February 2025. 14' x 12' drive-in door opens to a 3,000 sf space with 16' ceilings, 5" thick concrete floor, ADA restroom, small storage room with water heater and slop sink, and a small office up front. Office, restroom and storage have HVAC control.

Last remining lot in the well-established Sunset Hills Professional Centre office park. Located directly across from Sunset Hills Country Club on IL-157. Easy access from the Hwy. 5 minutes from I-270 and 10 minutes from downtown Edwardsville. Subject to the recorded covenants and restrictions for the office park. Broker Owned.Lot 7 in the Sunset Hills Professional Centre office park.

Office BuildingWell-located 1,619 SF office building with kitchenette, conference room, private offices, upstairs work space. Dedicated parking in the downtown corridor. Adjacent to restaurants, shops, and other businesses.Very attractive downtown location in growth market of Edwardsville IL. Located on S. Main street one block off of Main and Vandalia.

Medical OfficeHighly visible medical office building in Edwardsville. Easy access from IL-159 with 24,000+ ADT. Less than 1 mile from I-270 (Exit 12).Main Floor is a former urgent care facility that includes 7 exam rooms, x-ray and small procedure room (see floor plan.

Ironworks is a retail-focused shopping center offering a variety of commercial spaces for lease. With over 125 parking spaces and excellent visibility, it caters to a range of businesses, from shops to service providers and dining establishments.

Former Dental Suite Available on IL Rt. 157 with Visibility and Direct Access from this Edwardsville / Glen Carbon thoroughfare. Space includes 6 rooms, waiting/reception, nurse station and kitchen/break area.

Premier Office/Retail location in desirable downtown Edwardsville. At the lighted intersection of Vandalia and Main Street. Plentiful traffic counts and foot traffic. Surrounded by established and thriving office and retail businesses.At the intersection of Vandalia and Main Street - this is the premier space for visibility in the robust downtown Edwardsville market.

10.22 Acres of Land with 1,847 SF building For Sale or Build To SuitCurrently used as a nursery featuring a level site. Located a quarter a mile from Interstate 255 at Exit 3. Just one mile from Gateway Commerce Center.Sale Price: $766,500 ($1.

1,207 SF available at 120 N Main in Edwardsville. Located in a busy downtown corridor adjacent to multiple retailers/restaurants in the heart of Edwardsville.

Office for LeaseSpace for lease adjacent to the Mannie Jackson Center for the Humanities. 1/2 mile from the Madison County Courthouse and just a few blocks away from the main retail corridor of downtown Edwardsville.Over 11,000 ADT on Main St (IL-159). Monument signage.